Leprosy Diagnostic Landscape

Urinary M. leprae Antigen Detection

Detection of M. leprae phenolic glycolipid-I and lipoarabinomannan-like antigens excreted in urine. The method is non-invasive and requires no phlebotomy or sharps, but antigen concentrations in urine are low in leprosy.

Technology
Antigen Detection · Antigen assay
What it measures
PGL-I and lipoarabinomannan-like antigens in urine
Developer
Academic groups
Specimen
Urine
Development status
Assay in development
Regulatory status
None / RUO
Intended use
Non-invasive detection of infection without phlebotomy
Main limitation
Antigen levels in urine are low, and reported sensitivity is too low for diagnosis.
Linked publications
11
TPP-1, confirming leprosy
54.5 of 100, partial alignment
TPP-2, infection in contacts
56.0 of 100, partial alignment
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