Recombinase Polymerase Amplification (RPA)
Isothermal amplification at 37–42 °C with read-out in under 20 minutes, compatible with lateral flow detection and lyophilised reagent pellets. It has been reported for leprosy at the analytical stage only.
- Technology
- Molecular (NAAT) · Isothermal amplification
- What it measures
- M. leprae DNA
- Developer
- ICMR-National Institute of Research in Tribal Health (India)
- Specimen
- Capillary blood
- Development status
- Assay in development
- Regulatory status
- None / RUO
- Intended use
- Rapid point-of-care amplification with lateral flow read-out
- Main limitation
- Clinical validation in leprosy is minimal.
- Linked publications
- 1
- Collaborating institutions
- Leprosy Research Center, National Institute of Infectious Diseases (Tokyo, Japan), Maharaja Sayajirao University (India)
- TPP-1, confirming leprosy
- 41.5 of 100, partial alignment
- TPP-2, infection in contacts
- 48.5 of 100, partial alignment
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