Leprosy Diagnostic Landscape

High-Resolution Nerve Ultrasonography (HRUS)

Measurement of peripheral nerve cross-sectional area and echotexture by high-frequency ultrasound. It detects asymmetric nerve enlargement more reproducibly than palpation, including in pure neuritic disease in which cutaneous signs are absent.

Technology
Clinical & Functional · Imaging
What it measures
Peripheral nerve cross-sectional area and echotexture
Developer
In-house
Specimen
None (clinical/imaging)
Development status
LDT with clinical validation
Regulatory status
CE marked
Intended use
Objective assessment of peripheral nerve involvement, including pure neuritic disease
Main limitation
Depends on the operator, and nerve enlargement is not specific to leprosy.
Linked publications
91
TPP-1, confirming leprosy
40.0 of 100, partial alignment
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