Host Transcriptomic Signature (RNA)

Multigene expression signatures derived from peripheral blood or lesional tissue, evaluated for detecting infection and for predicting progression to clinical disease or to immunological reactions. Examples include the RISK4LEP blood signature from Leiden University Medical Center, which predicted leprosy years before clinical onset.

Technology

Host Response · Transcriptomics

What it measures

Multi-gene blood or lesional RNA expression signature

Developer

Academic consortia, including Fiocruz (Brazil) and Leiden University Medical Center (the Netherlands)

Specimen

Venous blood

Development status

Assay in development

Regulatory status

None / RUO

Intended use

Prediction of progression to clinical disease or to immunological reactions

Main limitation

Still at the discovery stage, and case-control designs tend to overstate accuracy.

Linked publications

44

Collaborating institutions

Instituto Lauro de Souza Lima (Bauru, Brazil), Colorado State University (Fort Collins, CO, USA)

TPP-1, confirming leprosy

20.0 of 100, low alignment

TPP-2, infection in contacts

16.5 of 100, low alignment

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