Leprosy Diagnostic Landscape

Skin Biopsy Histopathology (H&E and Fite–Faraco)

Examination of haematoxylin-and-eosin-stained and Fite–Faraco-stained sections for granulomatous inflammation, dermal nerve involvement and intralesional bacilli, permitting Ridley–Jopling classification. Requires an incisional or punch biopsy and dermatopathological expertise.

Technology
Microscopy & Histopathology · Histopathology
What it measures
Granulomatous pathology and acid-fast bacilli in tissue
Developer
In-house
Specimen
Punch biopsy
Development status
FDA/CE/WHO endorsed
Regulatory status
National approval
Intended use
Confirmation and Ridley–Jopling classification in clinically equivocal presentations
Main limitation
Needs a biopsy and a dermatopathologist, and findings overlap with other granulomatous skin diseases.
Linked publications
1541
TPP-1, confirming leprosy
26.5 of 100, low alignment
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