Clinical Diagnosis (WHO Cardinal Signs)
Diagnosis based on one or more of the three WHO cardinal signs: a hypopigmented or erythematous patch with definite sensory loss, thickened or tender peripheral nerves, and demonstrable acid-fast bacilli. It requires no consumables and is the reference procedure in national programmes.
- Technology
- Clinical & Functional · Clinical examination
- What it measures
- Hypopigmented or anaesthetic patch, thickened nerve and acid-fast bacilli
- Developer
- WHO programmatic standard
- Specimen
- None (clinical/imaging)
- Development status
- FDA/CE/WHO endorsed
- Regulatory status
- National approval
- Intended use
- Programmatic case detection and initiation of multidrug therapy at all health-care levels
- Main limitation
- Depends on the examiner, and other hypopigmented skin conditions are known to be misdiagnosed as leprosy.
- Linked publications
- 120
- TPP-1, confirming leprosy
- 57.5 of 100, partial alignment
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